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Antibacterial (Penicillin).
In clinical trials Amoxicillin/Clavulanic acid is clinically and bacteriological superior to Amoxicillin alone. Clavulanic acid enhances the antibacterial spectrum of Amoxicillin by rendering most β-lactamase producing isolates susceptible to the drug. Clavulanic acid alone possesses only weak antibacterial activity, except against Legionella spp., and certain strains of Branhamella catarrhalis, B. fragilis and Neisseria gonorrhoeae. The in-vitro synergy of Clavulanic acid combined with Amoxicillin has been confirmed in vivo in numerous experimental infections in animals.
